Tales from a New Amsterdam by Hunter S. Jones

The very beginning of this exciting Clustered Regularly Interspaced Palindromic Repeats (CRISPR) story dates back to the observations published by a Japanese research group in 1987. In this review, we aim to elucidate the current state of the CRISPR–Cas revolution in a tailor-made format from its discovery to exciting breakthroughs at the application level and further upcoming trends related to opportunities and challenges including ethical concerns.

The technology is evolving rapidly therefore, an overview of continuous improvement is important. Future applications of CRISPR–Cas will provide benefits for everyone and will save countless lives. The CRISPR–Cas system is extensively employed in the treatment of infectious and genetic diseases, in metabolic disorders, in curing cancer, in developing sustainable methods for fuel production and chemicals, in improving the quality and quantity of food crops, and thus in catering to global food demands. Undoubtedly, the applications of this system are endless. The ease, precision, affordability of this system is akin to a Midas touch for researchers editing genomes. The system has ignited a revolution in the field of genetic engineering.

Gene editing technology possesses a crucial potential to dramatically impact miscellaneous areas of life, and CRISPR–Cas represents the most suitable strategy. One such example is the Clustered Regularly Interspaced Palindromic Repeats (CRISPR)–Cas system, an adaptive immunity system in most archaea and many bacteria. According to Darwin’s theory, endless evolution leads to a revolution.

Tales from a New Amsterdam by Hunter S. Jones